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Duphaston (Dydrogesterone)

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Duphaston is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, Duphaston has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum.

Other names for this medication:
Climaston, Dabroston, Didrogesterona, Didrogesterone, Dirogest, Dufaston, Dydrogesteron, Dydrogesterone, Dydrogesteronum, Femaston, Femoston, Femphascyl, Gestatron, Isopregnenone

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Also known as: Dydrogesterone


Generic Duphaston is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, Generic Duphaston has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Generic Duphaston is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Generic name of Generic Duphaston is Dydrogesterone. Duphaston is also known as Dydrogesterone. Brand name of Generic Duphaston is Duphaston.


The dosage schemes below are meant as general recommendations. For optimal therapeutic effect, the dosages are to be adapted to the nature and severity of the disorder. In irregular cycles due to endogenous progesterone deficiency Generic Duphaston 5 to 10 mg is recommended especially in irregular cycles due to shortened luteal phase (ie pre-menopause). Treatment should be repeated for several cycles. In secondary amenorrhoea Administration of Generic Duphaston in combination with an estrogen is usually recommended as in these conditions endogenous progesterone deficiency is nearly always accompanied by estrogen deficiency. 0,05 mg ethinylestradiol is administered each day from the 1st to the 25th day of the cycle, and 5 mg Generic Duphaston is added twice daily from the 11th to the 25th day. Five days after the subsequent withdrawal bleeding, the same is repeated to imitate a natural cycle. In dysfunctional uterine bleeding The symptomatic treatment is aimed at stopping the bleeding and including a subsequent withdrawal bleeding. To stop bleeding: Generic Duphaston 10 mg together with 0,10 mg ethinylestradiol twice daily for 5 to 7 days. To prevent heavy bleedings: Generic Duphaston 5 mg twice daily from day 11 to day 25 of the cycle, if necessary, combined with an estrogen during the first half of the cycle. In post-menopausal complaints If for the symptomatic treatment of post-menopausal complaints estrogens are used (hormone replacement therapy A?A?A? HRT), Generic Duphaston 10 mg is used to counteract the effects of unopposed estrogens on the endometrium. A subsequent withdrawal bleeding is induced. On continuous estrogen therapy: Generic Duphaston 10 mg twice daily during the first 12 to 14 days of each calendar month. On cyclic estrogen therapy: Generic Duphaston 10 mg twice daily during the last 12 to 14 days of the treatment. If you want to achieve most effective results do not stop taking Generic Duphaston suddenly.


If you overdose Generic Duphaston and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Duphaston overdosage: diarrhea, stomach pain, hot and dry skin, confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, and muscle weakness or limp feeling.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Duphaston are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Duphaston if you are allergic to Generic Duphaston components. It is unknown how Generic Duphaston affects pregnant women or nursing mother. Do not take Generic Duphaston if you have undiagnosed vaginal bleeding or a history of thromboembolic disorders. Be careful with Generic Duphaston if you have cardiovascular, renal or hepatic impairment, diabetes mellitus, asthma, epilepsy and migraine, history of mental depression. Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Some medicines or medical conditions may interact with this medicine. Inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking. Do not stop taking Generic Duphaston suddenly.

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Fallopian tube smooth muscle contractions are physiologically related to transport of the ovum within the oviduct. Growth effects of electrically stimulated contraction on adult feline cardiocytes in primary culture. Three groups of 16 male college students performed 50 trials of the right-hand response with knowledge of results, under one of three left-arm conditions: (a) passive movement, (b) voluntary movement, and (c) no movement. We describe and present numerical simulations of a broadband version of the current (narrowband) PDS algorithm that can extend the capture range from 0.4 to 40 microns. A major suggestion was to develop an interdisciplinary seniors team to provide consultation on issues related to older adults to nursing staff, medical staff, and other interdisciplinary staff involved in patient care. Enantioselective synthesis of phenylacetamides in the presence of high organic cosolvent concentrations catalyzed by stabilized penicillin G acylase. Lower variability was found between studies with higher overall counts and this was highly significant. After three weeks, severe clinical changes were present and these changes increased throughout the treatment period. MRA was administered intravenously every 4 weeks for a total of 3 months.

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It is proposed that the aboriginal rock paintings in two areas of North America may have been produced by shamans while they were under the influence of hallucinogenic agents derived from plants. The syndrome described as distinct from Meleney Type I and II ulcers. Quantitative RT-PCR analysis confirmed decreased expression of 5 genes and an increase in expression of 1 gene upon SAP treatment. The mechanism(s) for the development of thermotolerance is not well understood, but earlier experimental evidence suggests that protein synthesis may play a role in its manifestation. A pilot study demonstrated a good internal and test-retest reliability of the questionnaire. CHRONOLOGICAL APPROACH TO COMPLEX TREATMENT OF PATIENTS WITH CHRONIC CHOLECYSTITIS IN COMBINATION WITH THE OPISTHORCHIASIS. Positive self-complexity was sensitive to methodological factors, namely, variations in stimulus materials used for self-ratings. An ever-increasing number of congenital heart disease patients are surviving into and beyond adolescence. Standard RPDs are not originally designed to accommodate a posterior implant load point. Molecular dynamics simulation of the solid-state topochemical polymerization of S2N2.

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Intercostal Lung Hernia after Video-assisted Thoracoscopic Lobectomy. Metabolic syndrome and osteoporotic fracture: a population-based study in China. Could some coral reefs become sponge reefs as our climate changes?. A piezoelectric activator in a small removable unilateral oral appliance conducts sound through the bone via the teeth to the good ear. The cellular basis of the enhancement of the antibody response will be discussed. Bacterial identification was made by sequence analysis of 16S rDNA fragments and by terminal restriction fragment length polymorphism analysis of polymerase chain reaction-amplified 16S rDNA fragments from adult guts. These results indicate that microsaccades are part of the oculomotor strategy by which the visual system acquires fine spatial detail. The dependence on experimental conditions, such as magnet field strength, pulse sequences, and data acquisition parameters, further complicates iron quantification with MRI.

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balthica shared fine structural characteristics with other Perkinsus species that clearly place it within this genus. Double-label immunocytochemistry indicated that GFAP-IR cells are a subpopulation of S-100-IR cells. A new category of large ITSs was recognized to exist in anuran species. A temporary pacemaker was required and complete resolution was achieved on steroid therapy with withdrawal of antimalarial therapy. More cases and prospective follow-up studies are needed to understand the evolvement of both neuropsychological and psychiatric symptoms in these patients. Acute Renal Injury in a 14-Year Old with HIV/AIDS and Tuberculosis. The present data suggests that gabapentin, verapamil and nifedipine all act to globally alter temperature regulation in steroid-dependent models of thermoregulatory function. Transfection of FRTL-5 rat thyroid cells with the human Ki-rasval12 fused to the rat TG promoter is rapidly followed by reduced expression of the differentiation markers thyroglobulin, thyroperoxydase and thyrotropin receptor, but not by fully malignant cell transformation.

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The prevalence of pipe smoking has declined since the 1960s, yet usage is still common regionally, especially among older populations. THE LONG-AWAITED Government response to the Griffiths report on community care is soon to be published, according to indications given by Health Minister David Mellor last week. Upon ingestion of PAH-contaminated soils, CYP1A1 is differentially induced in a tissue-specific and dose-dependent manner in duodenum, liver and kidney of minipigs and rats. The potential applications of integrated livestock databases in analysis, modelling, decision-support, and providing management information for veterinary services and livestock producers are discussed. We describe a reliable and simple technique of parastomal hernia repair using primary fascial repair with synthetic mesh that minimizes the known complications of infection and stomal stenosis while eliminating the need for peritoneal exploration, lysis of adhesions, and relocation of the stoma. Related experiments indicated that NSP1 mediates IRF3 degradation through a proteasome-dependent pathway. This procedure included release of the lateral joint capsule and transfer of the adductor tendon into the neck of the metatarsal. Enhanced dendritic action potential backpropagation in parvalbumin-positive basket cells during sharp wave activity. Evaluation of medically significant bacteria in colonoscopes after 8 weeks of shelf life in open air storage. Catechol estrogen conjugates and DNA adducts in the kidney of male Syrian golden hamsters treated with bactrim dosing mrsa 4-hydroxyestradiol: potential biomarkers for estrogen-initiated cancer.

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Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Complications of varicella occurred in six of nine placebo recipients, but in only two of nine interferon recipients ultram . We conclude that clotrimazole is highly effective treatment for chronic oral candidiasis. Dietary habits and oral hygiene as predictors of caries in 3-year-old children. Intra-articular fibrin, evaluated by immunohistochemistry, was significantly reduced in treated mice compared with control mice and correlated with both clinical and histological scorings.

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The study area consisted of the three metropolitan districts of the city of Izmir, Turkey. Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-alpha. Genes of interest were further validated by real-time polymerize chain reaction. Serum levels of zinc and selenium were analyzed during pregnancy in a second cohort of 71 hyperglycemic and 123 normoglycemic women, with a mean age and body mass index similar to those in the first cohort. These findings may be relevant to the increased prevalence of immune complexes in plasma of diabetic subjects and the late complications of diabetes mellitus. The purpose of this study was to evaluate our management algorithm. Cost-Effective In-House Neutralization Assay for the Confirmation of HBeAg. Advances such as correlative imaging and single photon emission computer tomography have increased its value and provided new clinical roles.

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To construct the melanoma antigen-1(MAGE-1) eukaryotic expression plasmid and express MAGE-1 in mouse melanoma B16 cells. Mutant mice lost body weight more quickly and showed exacerbated pulmonary injury even though there was no difference in Pneumocystis organism burden in the lung. Until more is known about these differences, complication rates should not be used to judge hospital quality of care in CABG surgery. Atypical forms of the disease have also been described, including those with associated sensory deficits, hearing loss, cerebellar hypoplasia, congenital heart defects, arthrogryposis, and bone fractures at birth. The aromatic residues in this region play a key role in the stabilization of the PCI-enzyme complex, whereas polar residues contribute little to this task. Cell cultures offer the advantage that enzyme activity can be measured in live cells in which the relative distribution of enzymes may more closely reflect that found in vivo. The adjuvant group demonstrated a reduction in the number and a delay in the appearance of the metastases. The phosphorus 31 nuclear magnetic resonance signal from the wrist bones was studied in controls covering a broad age range and in postmenopausal osteopenic women with or without osteoporosis. For example, preliminary data show that thin people in low- and middle-income countries such as India commonly experience type 2 diabetes.

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